Tag Archives: mouse

Christopher Schröder contributed to an article on the origin of human intronic CpG islands that are not present in mouse

Evolutionary Origin and Methylation Status of Human Intronic CpG Islands that Are Not Present in Mouse

Rademacher, K., Schröder, C., Kanber, D., Klein-Hitpass, L., Wallner, S., Zeschnigk, M., Horsthemke, B.

Genome Biol Evol 6, 1579–1588 (2014), doi:10.1093/gbe/evu125

Imprinting of the human RB1 gene is due to the presence of a differentially methylated CpG island (CGI) in intron 2, which is part of a retrocopy derived from the PPP1R26 gene on chromosome 9. The murine Rb1 gene does not have this retrocopy and is not imprinted. We have investigated whether the RB1/Rb1 locus is unique with respect to these differences.

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