Tag Archives: TLR13

06.11.2015 | Publication: Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

EMBO Reports 2015 Dec; 16(12): 1656–1663.
doi:10.15252/embr.201540861

Toll‐like receptor (TLR) 13 and TLR2 are the major sensors of Gram‐positive bacteria in mice. TLR13 recognizes Sa19, a specific 23S ribosomal (r) RNA‐derived fragment and bacterial modification of Sa19 ablates binding to TLR13, and to antibiotics such as erythromycin. Similarly, RNase A‐treated Staphylococcus aureus activate human peripheral blood mononuclear cells (PBMCs) only via TLR2, implying single‐stranded (ss) RNA as major stimulant. Continue reading